Protein name:
Receptor-interacting serine/threonine-protein kinase 3 ;
Alternative:
Receptor-interacting protein 3 (RIP-3) ;RIP-like protein kinase 3 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necroptosis-inducing complex. Binds TRAF2 is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes.
Function:
Essential for cellular necroptosis in response to TNF-alpha family of death-inducing cytokines. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Subcellular Location:
Cytoplasm
Cell membrane
Mitochondrion
Protein Attributes:
50:
MSCVKLWPSG | APAPLVSIEE | LENQELVGKG | GFGTVFRAQH | RKWGYDVAVK |
100:
IVNSKAISRE | VKAMASLDNE | FVLRLEGVIE | KVNWDQDPKP | ALVTKFMENG |
150:
SLSGLLQSQC | PRPWPLLCRL | LKEVVLGMFY | LHDQNPVLLH | RDLKPSNVLL |
200:
DPELHVKLAD | FGLSTFQGGS | QSGTGSGEPG | GTLGYLAPEL | FVNVNRKAST |
250:
ASDVYSFGIL | MWAVLAGREV | ELPTEPSLVY | EAVCNRQNRP | SLAELPQAGP |
300:
ETPGLEGLKE | LMQLCWSSEP | KDRPSFQECL | PKTDEVFQMV | ENNMNAAVST |
350:
VKDFLSQLRS | SNRRFSIPES | GQGGTEMDGF | RRTIENQHSR | NDVMVSEWLN |
400:
KLNLEEPPSS | VPKKCPSLTK | RSRAQEEQVP | QAWTAGTSSD | SMAQPPQTPE |
450:
TSTFRNQMPS | PTSTGTPSPG | PRGNQGAERQ | GMNWSCRTPE | PNPVTGRPLV |
500:
NIYNCSGVQV | GDNNYLTMQQ | TTALPTWGLA | PSGKGRGLQH | PPPVGSQEGP |
518:
KDPEAWSRPQ | GWYNHSGK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 3
ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 3
ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 3
CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 3
CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 3
CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 3
Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3
Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3
Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3
Monoclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3
Monoclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3
Monoclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 3
Protein for Human Receptor-interacting serine/threonine-protein kinase 3
Protein for Human Receptor-interacting serine/threonine-protein kinase 3
Protein for Human Receptor-interacting serine/threonine-protein kinase 3
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF LYS-50;INTERACTION WITH RIPK1
tissue :
Cervix carcinoma .
tissue :
Lymphocyte .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF LYS-50
tissue :
Aortic endothelium .
tissue :
Fetal brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY
4.
"The DNA sequence and analysis of human chromosome 14."
Heilig R.
,
Eckenberg R.
,
Petit J.-L.
,
Fonknechten N.
,
Da Silva C.
,
Cattolico L.
,
Levy M.
,
Barbe V.
,
De Berardinis V.
,
Ureta-Vidal A.
,
Pelletier E.
,
Vico V.
,
Anthouard V.
,
Rowen L.
,
Madan A.
,
Qin S.
,
Sun H.
,
Du H.
,
Pepin K.
,
Artiguenave F.
,
Robert C.
,
Cruaud C.
,
Bruels T.
,
Jaillon O.
,
Friedlander L.
,
Samson G.
,
Brottier P.
,
Cure S.
,
Segurens B.
,
Aniere F.
,
Samain S.
,
Crespeau H.
,
Abbasi N.
,
Aiach N.
,
Boscus D.
,
Dickhoff R.
,
Dors M.
,
Dubois I.
,
Friedman C.
,
Gouyvenoux M.
,
James R.
,
Madan A.
,
Mairey-Estrada B.
,
Mangenot S.
,
Martins N.
,
Menard M.
,
Oztas S.
,
Ratcliffe A.
,
Shaffer T.
,
Trask B.
,
Vacherie B.
,
Bellemere C.
,
Belser C.
,
Besnard-Gonnet M.
,
Bartol-Mavel D.
,
Boutard M.
,
Briez-Silla S.
,
Combette S.
,
Dufosse-Laurent V.
,
Ferron C.
,
Lechaplais C.
,
Louesse C.
,
Muselet D.
,
Magdelenat G.
,
Pateau E.
,
Petit E.
,
Sirvain-Trukniewicz P.
,
Trybou A.
,
Vega-Czarny N.
,
Bataille E.
,
Bluet E.
,
Bordelais I.
,
Dubois M.
,
Dumont C.
,
Guerin T.
,
Haffray S.
,
Hammadi R.
,
Muanga J.
,
Pellouin V.
,
Robert D.
,
Wunderle E.
,
Gauguet G.
,
Roy A.
,
Sainte-Marthe L.
,
Verdier J.
,
Verdier-Discala C.
,
Hillier L.W.
,
Fulton L.
,
McPherson J.
,
Matsuda F.
,
Wilson R.
,
Scarpelli C.
,
Gyapay G.
,
Wincker P.
,
Saurin W.
,
Quetier F.
,
Waterston R.
,
Hood L.
,
Weissenbach J.
more...
Nature421:601-607(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Thalamus .
6.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Blood .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : RIP HOMOTYPIC INTERACTION MOTIF;PHOSPHORYLATION AT SER-199;INTERACTION WITH RIPK1
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PYGL; GLUL AND GLUD1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT SER-199;INTERACTION WITH RIPK1
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION BY BIRC2/C-IAP1 AND BIRC3/C-IAP2;INTERACTION WITH BIRC2/C-IAP1; BIRC3/C-IAP2 AND XIAP/BIRC4
14.
"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase."
Sun L.
,
Wang H.
,
Wang Z.
,
He S.
,
Chen S.
,
Liao D.
,
Wang L.
,
Yan J.
,
Liu W.
,
Lei X.
,
Wang X.
Cell148:213-227(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MLKL;PHOSPHORYLATION AT SER-227;ACTIVE SITE;MUTAGENESIS OF ASP-142 AND SER-227
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN COMPLEX WITH PGAM5; RIPK1 AND MLKL;MUTAGENESIS OF LYS-50
16.
"Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."
Zhao Y.
,
Alonso C.
,
Ballester I.
,
Song J.H.
,
Chang S.Y.
,
Guleng B.
,
Arihiro S.
,
Murray P.J.
,
Xavier R.
,
Kobayashi K.S.
,
Reinecker H.C.
Inflamm. Bowel Dis.18:603-612(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ARHGEF2
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MLKL
18.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] MET-300 AND GLN-492